Taking into account the experience with children that have Down syndrome, as a doctor and dentist of the medical center FCSD and the investigation taken in the UIC as a doctoral thesis, it has built this article: “Comparative study of dental anomalies assessed with panoramic radiographs of Down syndrome and non-Down syndrome patients”. In this article it is highlighted that children with Down syndrome have more anomalies of number, shape, size and position of teeth. All this leads to make a periodic control of the dental health compulsory in these children with the purpose of preventing major problems.